[Football] Matt Le Tissier

[BadFish]

well you've quoted it now so no point deleting it so i'll offer you a personal apology .....i'm sorry , there is more to the spectrum than Autism as i'm assure you are aware ...sorry again ... Gates did an interview on American TV with his wife at the onset of covid , the whole tone of the interview was bizarre to say the least ,they both looked like they were on hallucinogens, the interviewer asked some questions along the lines of how are you going to get people who don't want to take the vaccine to take the vaccine..? , they looked at each other and she looked at the camera and said " oh , eventually we'll get their attention" sickening , about 2 weeks after that they split up and he disappeared from the limelight....i would not trust him as far as i could throw him , he's gone from a tech geek to a vaccine expert and is an overt depopulationist....what's not to like ..?? sorry again , nothing personal.

I appreciate the apology, thanks Syd.

This is a bit vague, a bizarre interview at the beginning of COVID and his wife leaving him. The only solid thing you have poster (I haven't seen the interview) is hkn saying 'eventually well get their attention' which could mean a lot of things.

Unless there is some evidence that his support of vaccines is anything more then he is just a tech geek who supports vaccines for COVID. Do you support vaccines for COVID?

I am not sure what a depopulationist is but if, as it sounds, it is some who believes the earth is over populated then from what I have read this is a legitimate concern in terms of resources and food. I have heard people suggest that his charity work is some form of culling process but again without evidence I have dismissed it as wild nonsense. Especially as an easy way for him to effect the global population is to cut back on the charitable work of the Gates Foundation.

Anyway you seem hesitant to actually post what you believe makes him abhorant so maybe we just leave it there?

 

[AmexRuislip]

He's recently joined Instagram, this should be fun

I needed a laugh after today's result!!!

 

[raymondo]

He's recently joined Instagram, this should be fun

I needed a laugh after today's result!!!

Too many pies, Matt!

 

[Harry Wilson's tackle]

Too many pies, Matt!

I did a bit of research on cannabidiol and can confirm it does f*** ALL.

File with coenzyme-Q10.
Degraded 100% in the gut and not absorbed into the body.

The man is a great fat muppet, with the brains of a Labrador, and the scruples of a car thief.

 

[dejavuatbtn]

A waste of a resource that could have benefitted the development of young footballers.

 

[ManOfSussex]

Glenn Hoddle was right about him.

 

[raymondo]

I did a bit of research on cannabidiol and can confirm it does f*** ALL.

File with coenzyme-Q10.
Degraded 100% in the gut and not absorbed into the body.

The man is a great fat muppet, with the brains of a Labrador, and the scruples of a car thief.

You're being a tad unfair to Labradors and car thieves, Harry

 

[BadFish]

I did a bit of research on cannabidiol and can confirm it does f*** ALL.

File with coenzyme-Q10.
Degraded 100% in the gut and not absorbed into the body.

The man is a great fat muppet, with the brains of a Labrador, and the scruples of a car thief.

We have been looking into this stuff for my son's anxiety and ADHD (he is keen on trying it, I am skeptical.

Harvard says this: https://www.health.harvard.edu/staying-healthy/cbd-products-are-everywhere-but-do-they-work

Does CBD work?​

There is evidence that CBD is quite helpful for some conditions, but certainly not all the conditions it is being promoted for. There's no evidence, for example, that CBD cures cancer, as some proponents claims. There is moderate evidence that CBD can improve sleep disorders, fibromyalgia pain, muscle spasticity related to multiple sclerosis, and anxiety. There is increasing data that CBD may help people overcome various addictions.

People commonly report that oral CBD helps relieve anxiety and pain and can lead to better sleep. CBD can be taken as a pill, found in a gummy, taken as a tincture, or smoked (which isn't a healthy way to consume it). One huge problem is that laboratory testing also shows that many products don't contain what's claimed on the label. For example, they may have less CBD than advertised. So, buyer beware.

Can you point me in the direction of where you read that it does f*** all?

 

[Harry Wilson's tackle]

We have been looking into this stuff for my son's anxiety and ADHD (he is keen on trying it, I am skeptical.

Harvard says this: https://www.health.harvard.edu/staying-healthy/cbd-products-are-everywhere-but-do-they-work

Does CBD work?​

There is evidence that CBD is quite helpful for some conditions, but certainly not all the conditions it is being promoted for. There's no evidence, for example, that CBD cures cancer, as some proponents claims. There is moderate evidence that CBD can improve sleep disorders, fibromyalgia pain, muscle spasticity related to multiple sclerosis, and anxiety. There is increasing data that CBD may help people overcome various addictions.

People commonly report that oral CBD helps relieve anxiety and pain and can lead to better sleep. CBD can be taken as a pill, found in a gummy, taken as a tincture, or smoked (which isn't a healthy way to consume it). One huge problem is that laboratory testing also shows that many products don't contain what's claimed on the label. For example, they may have less CBD than advertised. So, buyer beware.

Can you point me in the direction of where you read that it does f*** all?

I have good news for you if you read all this carefully.....

First, the kind of language describing effects you post above is absolutely typical of discussions around unproven 'medicines' where positive findings are derived from small flawed studies, case reports, and personal testimonials. That doesn't mean they have no value but....

When a substance is 'popular' and apparently safe, it often ends up in the category of nutraceutical. This is essentially a food supplement. This is how the UK's MHRA classifies CBD, albeit its statements are nuanced:

MHRA statement on products containing cannabidiol (CBD)

www.gov.uk

This does not mean that CBD cannot be prescribed as a medicine. In fact to be prescribed as a medicine, or sold as a neutraceutical or food additive all the seller needs to do in the UK is show that it is safe, not that it is effective. In the US they have always required a new drug be 'better' than what is available (safer and/or more effective). Albeit that may change now they have a nut job in charge of the NIH. But I digress.

There are countless numbers of products that fall into this sort of category. Where I work we used to ask our year 1 students to evaluate the clinical value of a range of 'natural' medicines. We dropped it in the end because there is a mountain of literature claiming clinical benefit from these substances and students were just listing all the benefits in their presentations without examining the evidence. Feverfew was one example. Evening primrose oil another. Now get this. I take evening primrose oil and glucosamine and chondroitin. Why? Because they are safe and maybe (who knows) they may help my joints. Do they work? No idea. Albeit I am getting a knee replacement in 2 days....

Stepping back we also have TCM (traditional Chinese medicine). Again the claims are legion.

The bottom line is that to be sure a medicine works we need randomized blinded trials. For a 'powerful' drug with side effects there is no way you could get it approved to be prescribed without published evidence of benefit and safety.

If the new drug is weak but apparently free of side effects, it may be possible to prescribe it without any real evidence of benefit.

I am sorry to say that the glowing testimonials are likely to be chance. If a drug has reliable reproducible benefit this would be clear from published data. If the 'evidence' is the testimonials of evangelical believers, we are getting into religion territory, where belief is king.

My ex wife's mother got ankylosing spondylitis and swears that she was cured by taking evening primrose oil. No doubt there are dozens of similar reports in the news media, on promotional web sites, etc. And yet I take evening primrose oil. Why? The answer really is why not? I used to by a lottery ticket and stopped only when I forgot. If there is possible benefit, not matter how unlikely, and no costs (except trivially financial), we you can do the calculations.

But real medicines are backed by real large scale clinical trial data. That means thousands of patients, not dozens. Some of my colleagues are clinical researchers. There are issues with small scale clinical trials because they are done on shoestring budgets, and maintaining blinding and randomization is hard. This is because the work is farmed out to scientifically untrained junior colleagues who mess things up. I was an advisor on a clinical trial recently. It had only a few dozen volunteers. The randomization was done properly, but it failed and caused clustering (just like when you toss a coin ten times and get a run of 5 heads - random chance but if you do 5 of your tests on the same day you introduce a 'day' effect. I have examples of this but again I digress). Had I not spotted it and got the study re randomized using a restriction (minimum consecutive subjects assigned to one group restricted to 2) the study was almost guaranteed to generate a false finding. Not a lot of people know about this stuff. I happen to teach it and publish on it.

So should you abandon your CBD pursuit for you son? No. If you can obtain reliable CBD (and the MHRA warns about unreliable products) go for it (under medical supervision). There may be benefit. This may have a placebo element but that is fine. Using belief to heal is fine. The consultant I have dealt with for my back has suggested that there is no anatomical reason for my pain, and suggests it it generated by anxiety relating to my gait relating to my knee, plus anxiety over the real arthritis I have in my spine that should not be causing me pain. Since I was told this, the pain has been less of a problem. I have no reason to be anxious but I am because I have endogenous anxiety. So I am happy to play around with alt.medicine and suchlike. The pain goes away when I use my myovi (a real fun device). I frankly don't care how that is supposed to work. I don't believe in god but if I did I would pray. Why not? Medicine is not science. It uses science as part of the practice, but scientific proof is not necessary. All you need to do is make the patient better and do no harm (which means intervene so and adverse effects are outweighed by the good effects). I am a scientist so in my game I am after proofs, and I don't have to heal anyone.

So best wishes with your son and the CBD.

I should add that other cannabis products do have real pharmacological actions. Unfortunately there is more resistance to their approval - because the effects are obvious and some are considered to be adverse. I am talking about THC. From what I can see (and I know someone who own a patent on use of a form of CBD) the interest in CBD has built on the back of the cannabinoid and endocannabinoid research area, which attracts a mix to top people like Steve Alexander and Roger Pertwee, plus a fair number of old hippies who like a spliff.

 

[wehatepalace]

I did a bit of research on cannabidiol and can confirm it does f*** ALL.

File with coenzyme-Q10.
Degraded 100% in the gut and not absorbed into the body.

The man is a great fat muppet, with the brains of a Labrador, and the scruples of a car thief.

Just a point of note, Labradors are a very intelligent dog breed, that’s why they are so trainable, other than that carry on sir

 

[BadFish]

I have good news for you if you read all this carefully.....

First, the kind of language describing effects you post above is absolutely typical of discussions around unproven 'medicines' where positive findings are derived from small flawed studies, case reports, and personal testimonials. That doesn't mean they have no value but....

When a substance is 'popular' and apparently safe, it often ends up in the category of nutraceutical. This is essentially a food supplement. This is how the UK's MHRA classifies CBD, albeit its statements are nuanced:

MHRA statement on products containing cannabidiol (CBD)

www.gov.uk

This does not mean that CBD cannot be prescribed as a medicine. In fact to be prescribed as a medicine, or sold as a neutraceutical or food additive all the seller needs to do in the UK is show that it is safe, not that it is effective. In the US they have always required a new drug be 'better' than what is available (safer and/or more effective). Albeit that may change now they have a nut job in charge of the NIH. But I digress.

There are countless numbers of products that fall into this sort of category. Where I work we used to ask our year 1 students to evaluate the clinical value of a range of 'natural' medicines. We dropped it in the end because there is a mountain of literature claiming clinical benefit from these substances and students were just listing all the benefits in their presentations without examining the evidence. Feverfew was one example. Evening primrose oil another. Now get this. I take evening primrose oil and glucosamine and chondroitin. Why? Because they are safe and maybe (who knows) they may help my joints. Do they work? No idea. Albeit I am getting a knee replacement in 2 days....

Stepping back we also have TCM (traditional Chinese medicine). Again the claims are legion.

The bottom line is that to be sure a medicine works we need randomized blinded trials. For a 'powerful' drug with side effects there is no way you could get it approved to be prescribed without published evidence of benefit and safety.

If the new drug is weak but apparently free of side effects, it may be possible to prescribe it without any real evidence of benefit.

I am sorry to say that the glowing testimonials are likely to be chance. If a drug has reliable reproducible benefit this would be clear from published data. If the 'evidence' is the testimonials of evangelical believers, we are getting into religion territory, where belief is king.

My ex wife's mother got ankylosing spondylitis and swears that she was cured by taking evening primrose oil. No doubt there are dozens of similar reports in the news media, on promotional web sites, etc. And yet I take evening primrose oil. Why? The answer really is why not? I used to by a lottery ticket and stopped only when I forgot. If there is possible benefit, not matter how unlikely, and no costs (except trivially financial), we you can do the calculations.

But real medicines are backed by real large scale clinical trial data. That means thousands of patients, not dozens. Some of my colleagues are clinical researchers. There are issues with small scale clinical trials because they are done on shoestring budgets, and maintaining blinding and randomization is hard. This is because the work is farmed out to scientifically untrained junior colleagues who mess things up. I was an advisor on a clinical trial recently. It had only a few dozen volunteers. The randomization was done properly, but it failed and caused clustering (just like when you toss a coin ten times and get a run of 5 heads - random chance but if you do 5 of your tests on the same day you introduce a 'day' effect. I have examples of this but again I digress). Had I not spotted it and got the study re randomized using a restriction (minimum consecutive subjects assigned to one group restricted to 2) the study was almost guaranteed to generate a false finding. Not a lot of people know about this stuff. I happen to teach it and publish on it.

So should you abandon your CBD pursuit for you son? No. If you can obtain reliable CBD (and the MHRA warns about unreliable products) go for it (under medical supervision). There may be benefit. This may have a placebo element but that is fine. Using belief to heal is fine. The consultant I have dealt with for my back has suggested that there is no anatomical reason for my pain, and suggests it it generated by anxiety relating to my gait relating to my knee, plus anxiety over the real arthritis I have in my spine that should not be causing me pain. Since I was told this, the pain has been less of a problem. I have no reason to be anxious but I am because I have endogenous anxiety. So I am happy to play around with alt.medicine and suchlike. The pain goes away when I use my myovi (a real fun device). I frankly don't care how that is supposed to work. I don't believe in god but if I did I would pray. Why not? Medicine is not science. It uses science as part of the practice, but scientific proof is not necessary. All you need to do is make the patient better and do no harm (which means intervene so and adverse effects are outweighed by the good effects). I am a scientist so in my game I am after proofs, and I don't have to heal anyone.

So best wishes with your son and the CBD.

I should add that other cannabis products do have real pharmacological actions. Unfortunately there is more resistance to their approval - because the effects are obvious and some are considered to be adverse. I am talking about THC. From what I can see (and I know someone who own a patent on use of a form of CBD) the interest in CBD has built on the back of the cannabinoid and endocannabinoid research area, which attracts a mix to top people like Steve Alexander and Roger Pertwee, plus a fair number of old hippies who like a spliff.

Thank you I will have a good read after dinner.

I will ask you to remember though that on the other side of the arguement sits Tiss so it will have to be a powerful read

 

[BN9 BHA]

Just a point of note, Labradors are a very intelligent dog breed, that’s why they are so trainable, other than that carry on sir

I think Matt LeTiss may have the appetite of a Labrador though

 

[BN9 BHA]

Who mentioned brains? This product must be good

 

[BadFish]

I have good news for you if you read all this carefully.....

First, the kind of language describing effects you post above is absolutely typical of discussions around unproven 'medicines' where positive findings are derived from small flawed studies, case reports, and personal testimonials. That doesn't mean they have no value but....

When a substance is 'popular' and apparently safe, it often ends up in the category of nutraceutical. This is essentially a food supplement. This is how the UK's MHRA classifies CBD, albeit its statements are nuanced:

MHRA statement on products containing cannabidiol (CBD)

www.gov.uk

This does not mean that CBD cannot be prescribed as a medicine. In fact to be prescribed as a medicine, or sold as a neutraceutical or food additive all the seller needs to do in the UK is show that it is safe, not that it is effective. In the US they have always required a new drug be 'better' than what is available (safer and/or more effective). Albeit that may change now they have a nut job in charge of the NIH. But I digress.

There are countless numbers of products that fall into this sort of category. Where I work we used to ask our year 1 students to evaluate the clinical value of a range of 'natural' medicines. We dropped it in the end because there is a mountain of literature claiming clinical benefit from these substances and students were just listing all the benefits in their presentations without examining the evidence. Feverfew was one example. Evening primrose oil another. Now get this. I take evening primrose oil and glucosamine and chondroitin. Why? Because they are safe and maybe (who knows) they may help my joints. Do they work? No idea. Albeit I am getting a knee replacement in 2 days....

Stepping back we also have TCM (traditional Chinese medicine). Again the claims are legion.

The bottom line is that to be sure a medicine works we need randomized blinded trials. For a 'powerful' drug with side effects there is no way you could get it approved to be prescribed without published evidence of benefit and safety.

If the new drug is weak but apparently free of side effects, it may be possible to prescribe it without any real evidence of benefit.

I am sorry to say that the glowing testimonials are likely to be chance. If a drug has reliable reproducible benefit this would be clear from published data. If the 'evidence' is the testimonials of evangelical believers, we are getting into religion territory, where belief is king.

My ex wife's mother got ankylosing spondylitis and swears that she was cured by taking evening primrose oil. No doubt there are dozens of similar reports in the news media, on promotional web sites, etc. And yet I take evening primrose oil. Why? The answer really is why not? I used to by a lottery ticket and stopped only when I forgot. If there is possible benefit, not matter how unlikely, and no costs (except trivially financial), we you can do the calculations.

But real medicines are backed by real large scale clinical trial data. That means thousands of patients, not dozens. Some of my colleagues are clinical researchers. There are issues with small scale clinical trials because they are done on shoestring budgets, and maintaining blinding and randomization is hard. This is because the work is farmed out to scientifically untrained junior colleagues who mess things up. I was an advisor on a clinical trial recently. It had only a few dozen volunteers. The randomization was done properly, but it failed and caused clustering (just like when you toss a coin ten times and get a run of 5 heads - random chance but if you do 5 of your tests on the same day you introduce a 'day' effect. I have examples of this but again I digress). Had I not spotted it and got the study re randomized using a restriction (minimum consecutive subjects assigned to one group restricted to 2) the study was almost guaranteed to generate a false finding. Not a lot of people know about this stuff. I happen to teach it and publish on it.

So should you abandon your CBD pursuit for you son? No. If you can obtain reliable CBD (and the MHRA warns about unreliable products) go for it (under medical supervision). There may be benefit. This may have a placebo element but that is fine. Using belief to heal is fine. The consultant I have dealt with for my back has suggested that there is no anatomical reason for my pain, and suggests it it generated by anxiety relating to my gait relating to my knee, plus anxiety over the real arthritis I have in my spine that should not be causing me pain. Since I was told this, the pain has been less of a problem. I have no reason to be anxious but I am because I have endogenous anxiety. So I am happy to play around with alt.medicine and suchlike. The pain goes away when I use my myovi (a real fun device). I frankly don't care how that is supposed to work. I don't believe in god but if I did I would pray. Why not? Medicine is not science. It uses science as part of the practice, but scientific proof is not necessary. All you need to do is make the patient better and do no harm (which means intervene so and adverse effects are outweighed by the good effects). I am a scientist so in my game I am after proofs, and I don't have to heal anyone.

So best wishes with your son and the CBD.

I should add that other cannabis products do have real pharmacological actions. Unfortunately there is more resistance to their approval - because the effects are obvious and some are considered to be adverse. I am talking about THC. From what I can see (and I know someone who own a patent on use of a form of CBD) the interest in CBD has built on the back of the cannabinoid and endocannabinoid research area, which attracts a mix to top people like Steve Alexander and Roger Pertwee, plus a fair number of old hippies who like a spliff.

Thank you, on this advice I will get the boy some CBD and myself some weed. Did I read it right?

Jokes of course. I get what you are saying and will discuss with Mrs Badfish and Badfish jnr.

 

[Harry Wilson's tackle]

Thank you, on this advice I will get the boy some CBD and myself some weed. Did I read it right?

Jokes of course. I get what you are saying and will discuss with Mrs Badfish and Badfish jnr.

If you want to chat about this please PM me anytime. Well, probably best give me till early May to recover from my knee replacement - my judgement and wisdom are not at their best when under the influence of morphine

 

[Dick Swiveller]

Who mentioned brains? This product must be good

If Merson takes them, that is a red FLAG. Side effects are a stream of blithering gibberish coming from the mouth, a contempt of your highly paid job caused by lethargy when it comes to learning players' names and, ultimately, becoming a boorish tit.

 

[BadFish]

If Merson takes them, that is a red FLAG. Side effects are a stream of blithering gibberish coming from the mouth, a contempt of your highly paid job caused by lethargy when it comes to learning players' names and, ultimately, becoming a boorish tit.

Sorry are these side affects or symptoms that can can cured?

Asking for a friend (NSC).

 

[Dick Swiveller]

Sorry are these side affects or symptoms that can can cured?

Asking for a friend (NSC).

Mersonitis is a rare condition that affects 1 in 70 million people in the UK so data is unavailable

 

[bhafc99]

Too many pies, Matt!

Who else went to his testimonial – Southampton vs Brighton at The Dell?

I remember the Stains fans singing how "he's scored some f***ing amazing goals", to which we replied "he's eaten some f***ing big pies".

 

[Greg Bobkin]

This next business could be revenue-defining.